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Sunday, March 21, 2010

Overexpression of "Klotho" Cures Age-Related Diseases and Extends Lifespan

Overexpression of the Klotho gene has repeatedly been shown to prevent, delay and even cure (1) osteoporosis, atherosclerosis, Alzheimer's (4), muscle loss and heart dysfunction. This has been investigated repeatedly for over 20 years. What research is currently being done on viral/ZFN vector delivery to overexpress this gene in primate models, or in human safety trials? From what I can tell, very little, or none at all.


I noticed that nearly every research article, directly following pronouncement that klotho extends health and life, follows that statement with "but we don't know why" (1,2,3,4).


Researchers are obsessed with understanding why. Researcher want to know why this hormone apparently cures everything. But there are no studies into whether it can be used today... on people who are dying today. FAIL: intellectual curiosity is trumping the needs of the terminally ill.

(1) "In Vivo klotho Gene Delivery Protects against Endothelial Dysfunction in Multiple Risk Factor Syndrome" (2000) Yuichiro Saito, et al.
(2) "Suppression of Aging in Mice by the Hormone Klotho" (2005) Hiroshi Kurosu, et al. doi:10.1126/science.1112766
(3) "Klotho as a regulator of oxidative stress and senescence" (2008) Makoto Kuro-o doi: 10.1515/BC.2008.028
(4) P4-186: Modulating Klotho expression to protect against age-induced neurodegeneration" (2008) Gwendalyn D. King


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